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Research Associate I / II, Downstream Process Development

IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company pioneering the development of engineered IgM antibodies for the treatment of cancer, infectious diseases, and autoimmune and inflammatory diseases. IgM antibodies have inherent properties that we believe may enable them to bind more strongly to targets on the surface of cells than comparable IgG antibodies. We believe our proprietary IgM antibody technology platform is particularly well suited for developing T cell engagers, receptor cross-linking agonists, targeted cytokines, and target neutralizers. Our lead product candidate, Imvotamab, is a bispecific T cell engaging IgM antibody targeting CD20 and CD3 proteins, and it is currently in two Phase 2 clinical trials for the treatment of relapsed and/or refractory diffuse large B cell lymphoma and follicular lymphoma. Our second product candidate is IGM-8444, an IgM antibody targeting Death Receptor 5 (DR5) for the treatment of patients with relapsed and/or refractory solid and hematologic malignancies, and it is currently in a Phase 1 clinical trial. Also in our product pipeline is IGM-7354 and IGM-2644. IGM-7354 is an anti-PD-L1 IgM antibody that targets the delivery of interleukin-15 (IL-15) cytokines to the area of PD-L1 expressing cells for the treatment of patients with solid and hematologic malignancies. IGM-2644 is a bispecific T cell engaging IgM antibody targeting CD38 and CD3 proteins for the treatment of patients with multiple myeloma.Position SummaryAs a Research Associate with experience in process development particularly in the context of antibody and antibody-like biologics. The ideal candidate will have a solid background in protein purification and bioanalytical techniques used to characterize biologics. This is a key position in Process Development and Manufacturing and will have the opportunity to collaborate across groups to contribute to multiple fast-moving drug discovery projects. You will report to a Senior Scientist. \nResponsibilities: Support the design and development of scalable purification processes for the production of IgM/IgA molecules.Execute studies for key unit operations in the purification process, using high throughput formats where appropriate.Quantify and characterize protein and antibody targets using typical analytical methods in protein chemistry.Operate and maintain instrumentation for the purification and analysis of antibodies.Keep track of inventory records of supplies, materials, and prepare requisitions as necessary.Keep accurate and current records of executed studies and share data with management and team members.Searches the literature to identify alternative methodologies and solve scientific problems, establish, and qualify assays.Generate data for and author technical development reports, process validation protocols, and reports.Learns new techniques as the job requires. Qualifications: Level commensurate with experience.BS degree in chemical / biochemical engineering, biochemistry, or related field with experience in the biopharma industry, preferably in a fast-paced startup environment.RA I: BS with 0+ years or Associates with 5+ years of experience. RA II: BS with 2+ years, MS with 0+ years, or Associates with 7+ years of experience.Capability in the core purification unit operations including chromatography, normal flow, and tangential flow filtration, with hands-on experience using and maintaining AKTA (AVANT, Pure, Ready) systems with Unicorn software.Demonstrated experience with analytics and characterization of biomolecules (SDS-PAGE, Western Blot, residual Host Cell Proteins, residual DNA, HPLC).Experience with designing and performing DOEs is a plus.Proficiency in the use of electronic lab notebook platforms (e.g. Benchling) is a plus.Excellent organization, interpersonal, and communication skills (both written and verbal) and ability to clearly and effectively present data at group and department meetings.Self-starter with ability to work independently, following general instructions for new assignments, and effectively function in team environment.Being a consummate team player and respectful of others is a must.Must be able to commute to Mountain View.The typical annual salary range for this full-time position is $65,000 - $105,000, plus eligibility for cash and equity incentives.This range reflects the characteristics of the job, such as required skills and qualifications and is based on the office location noted in this job posting. The range may also be adjusted based on applicant's geographic location.Actual individual pay is determined by demonstrated experience and internal equity alignment.\nWe offer a fast-paced, collaborative, team-based and family-like work environment. One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits with a variety of options: · Medical, dental and vision insurance.· The full premium amount for our employees and their dependents is covered by IGM· FSA (Flexible Spending Account)· STD, LTD, Basic Life and AD&D Insurance, Supplemental Life and AD&D Insurance· 401(k) Plan· 120 hours of Paid Time Off, 5 sick days per year, 11 holidays· Cell phone & internet subsidy· Employee Referral Bonus Program· Annual training budget for professional development· Commuter Benefit· Annual bonus program· New hire stock options IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. All qualified applicants will receive consideration for employment.

Job Type
Full Time
Salary
N/A
Experience
N/A
Posted
17 days ago

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