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Scientist Senior

Overview

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Scientist Senior to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS) located in Bethesda, MD.

Overall Position Summary and Objectives Under this task order, the contractor will independently provide support services to satisfy the overall operational objectives of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The primary objective is to provide services and deliverables through performance of support services.

Deliverables:

Work products and documents related to designing and carrying out research, including purified proteins, sample quality assessments, biochemical assay data, light and electron microscopic data, molecular simulation data, preparing reports, papers, and presentations. - Ad-Hoc

Work products and documents related to performing advanced quantitative analysis and biochemical and microscopy data including molecular reconstructions and theoretical models. - Ad-Hoc

Work products and documents related to collecting, analyzing and interpreting data, interacting with the scientific community, training junior staff including and participating in scientific meetings. - Ad-Hoc

Work Details:

Supports the planning and execution of research experiments in the context of the laboratory's overall research program.

Evaluate new techniques, instruments, and software for potential incorporation into current SOP.

Perform biochemical assays, protein expression and purification, assess sample quality, prepare samples for analytical studies included but no limited to spectroscopy (absorption, fluorescence, circular dichroism), determine binding constants by various methods (spectroscopic, analytical centrifugation, size-exclusion chromatography, SEC-MALS, DLS and related). 1

Setup workflows for sample preparation for light and electron microscopy including purified proteins, cultured cells, tissues, for confocal fluorescence and for negative stain and cryogenic electron microscopy. 2

Conduct computational structural studies of proteins complexes, macromolecular assemblies, and cellular processes by using processed light and electron microscopy data. Make 3D reconstructions. 3

Design new research projects and establish collaborations with intramural community to help fulfill the mission of the Protein Expression Lab.

Supports laboratory staff on research projects and techniques.

Work with staff to develop oral presentations and posters for internal and external groups/conferences.

Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments.

Maintain and support staff for conducting computational analysis via molecular modeling, docking and molecular dynamics to gain insights into biomolecular mechanisms and structure-activity relationships.

Maintains laboratory equipment and the training of others in their use.

Train staff on the proper usage of laboratory instruments and equipment.

Assists in maintaining adequate space and facilities for ongoing and projected research studies.

Manage scientific equipment and resources (e.g. reagents, stocks of frozen sells, animal samples) including acquisition, documentation and storage.

Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts.

Work with staff to confirm assay results and evaluate new techniques, instruments and protocols, search literature, propose design and test alternative assays for difficult screening targets; confirm assay results; develop secondary assays.

Write technical reports and prepare manuscripts.

Coordinates with junior staff to modify research protocols.

Presents research at national scientific meetings and symposia.

Provides interpretation of results, guidance, and scientific support to the management team.

Search existing literature for new and/or relevant techniques.

Mentors junior level scientists.

Perform biochemical assays, protein expression and purification, assess sample quality, prepare samples for analytical studies included but not limited to spectroscopy (absorption, fluorescence, circular dichroism), determine binding constants by various methods (spectroscopic, analytical centrifugation, size-exclusion chromatography, SEC-MALS, DLS and related). 4

Setup workflows for sample preparation for light and electron microscopy including purified proteins, cultured cells, tissues, for confocal fluorescence and for negative stain and cryogenic electron microscopy. 5

Conduct computational structural studies of proteins complexes, macromolecular assemblies, and cellular processes by using processed light and electron microscopy data. Make 3D reconstructions.

Maintain and support staff for conducting computational analysis via molecular modeling, docking and molecular dynamics to gain insights into biomolecular mechanisms and structure-activity relationships.

Design new research projects and establish collaborations with intramural community to help fulfill the mission of the Protein Expression Lab.

1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked

Minimum Education

Master's

Additional Qualifications:

Certifications & Licenses

Ph.D. degree in a scientific field.

Field of Study

Biochemical Sciences

Biology

Software

MS Office

Skills

Excellent analytical, organizational and time managements skills.

Benefits

100% Medical Dental & Vision Coverage for Employees

Educational Benefits for Career Growth

Paid Time Off (Including Holidays)

Employee Referral Bonus

Profit Sharing

401K Matching

Flexible Spending Accounts:

Healthcare (FSA)

Parking Reimbursement Account (PRK)

Dependent Care Assistant Program (DCAP)

Transportation Reimbursement Account (TRN)

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

Job Type
Full Time
Salary
N/A
Experience
N/A
Posted
75 days ago

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