Sr Scientist R&D, Insect Cell Protein Expression.

About Meridian

Meridian Bioscience is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic products. We are dedicated to developing and delivering better solutions that give answers with speed, accuracy and simplicity that are redefining the possibilities of life from discovery to diagnosis. We are looking for talented and passionate individuals that help drive our vision. Our innovative culture will allow interested candidates to discover and create, through collaboration, cutting edge solutions to tough problems.

Job Summary

As part of the R&D team, the Sr Scientist position will drive research projects aimed at developing the expansion of our immunological reagents portfolio while providing documentation accordingly to ISO standards. The role will be responsible for conducting research and development related to small scale expression and purification of proteins using insect cell culture, including protein characterization and functional assay development. The position will be required to work independently at the bench as well as effectively collaborate through communication of scientific findings to internal and external groups.

Relationships:

Key Stakeholders

This position will collaborate with the Immuno Research and Development team members to design experiments, execute experiments, and analyze generated data for assigned projects.

The position will collaborate with different internal groups including Manufacturing and Quality to complete development projects.

Line Management

This position reports to the Director, Immuno R&D Lifescience

This position can be an independent contributor or manage Senior Research Associates and Research Associates as assigned.

Key Duties

Assist the Director on a variety of scientific projects

Provides technical leadership for allocated new product development activities

Establishes and disseminate technical knowledge and good laboratory practices in the group.

Follows independently SOP (protocols, MSOP and ASOP)

Independent troubleshooting of experiment

Keep accurate laboratory records

Work to ISO13485 standards and understand their requirements

Participation in general laboratory meetings

Design, develop and optimize processes for the expression and purification of new proteins in insect cells.

Support scale-up activities for large scale protein manufacturing.

Develop methodologies that characterize protein expression and protein quality.

Perform routine laboratory maintenance and management including ordering of materials, consumables stock monitoring, cleaning, and routine maintenance of laboratory equipment.

Other tasks as assigned.

Qualifications

Knowledge, Skills and Abilities:

Extensive hands-on experience with cloning, protein expression, and purification using insect cell expression systems such as S2, Sf9 or Sf21.

Strong skills for expression of proteins in Baculovirus/Insect cell systems, this includes virus generation and amplification using pFastBac or similar systems.

Demonstrated ability to purify and characterize proteins. A knowledge of AKTA systems preferred.

Working knowledge of bioprocessing including process scale up preferred.

Demonstrated ability to design, document, and execute experiments. Must be able to accurately analyse and interpret generated results.

Work effectively in collaborative environment, communicate scientific findings freely, and instruct/train personnel as required.

Open to learn and develop new techniques to support the development and improvement of immunological IVD reagents.

Well-organized, able to manage multiple projects, calm under pressure.

Proficient in technical writing, concise and accurate oral and written reporting of technical data.

Demonstrate ownership of activities and responsibilities

Good understanding of chemical principles involved in protein expression and purification.

Education and Experience:

A Bachelors, Masters, or Ph.D. from an accredited institution in a relevant scientific discipline such as Biochemistry, Molecular Biology, Protein Chemistry, etc. is required.

Required is 10+ years of relevant research or industrial experience with a bachelors, 8+ years with a Masters, or 2+ years with a Ph.D.

Life science, Biotech or similar industry experience would be preferred

Requirements (Physical, Mental and Environmental Demands):

Travel

Travel is minimal. Travel between business units, travel to scientific meetings, or travel for commercial meetings may be required.

Physical

Primary work requirements include working in a laboratory setting.

Must be able to perform repetitive movements including pipetting and typing.

Ability to concentrate, analyze, and solve complex issue throughout the day.

Other

May be required to work outside of normal business hours when needed and to support business needs.

We are proud to be an EEO/AA employer Minority/Female/Disability/Veteran. We maintain a drug-free workplace and perform pre-employment substance abuse testing.